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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPX2 All Species: 22.73
Human Site: S250 Identified Species: 50
UniProt: Q9ULW0 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9ULW0 NP_036244.2 747 85653 S250 I G Q P V K K S V S Q V T K S
Chimpanzee Pan troglodytes XP_001153533 746 85517 S249 I G Q P V K K S V S Q V T K S
Rhesus Macaque Macaca mulatta XP_001109645 746 85683 S249 I G Q P V K K S V S Q V T K S
Dog Lupus familis XP_850934 748 86144 S251 I G Q P V K K S V I Q V T K S
Cat Felis silvestris
Mouse Mus musculus NP_082385 745 85876 S252 P G Q P V K K S T S Q V T K T
Rat Rattus norvegicus NP_001101260 744 85432 S250 P G Q P V K K S T S Q V T K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516385 623 69684 Q221 P T C K S A A Q L E A E E L E
Chicken Gallus gallus NP_989768 739 85048 G249 Q P M K R A V G Q V T K P V D
Frog Xenopus laevis NP_001086751 715 81991 F230 T K P V D F H F K T D D R L K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798362 948 108486 T450 A V K A V V P T T K P V G F T
Poplar Tree Populus trichocarpa XP_002327911 811 91572 N258 K N V A G T T N L A Q E N Q A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 97.5 90.3 N.A. 79.2 79.1 N.A. 40.1 57.5 53.8 N.A. N.A. N.A. N.A. N.A. 31.6
Protein Similarity: 100 99.3 98.6 93.9 N.A. 87.6 87.4 N.A. 53 72.5 70 N.A. N.A. N.A. N.A. N.A. 49.4
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. 0 0 0 N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 6.6 0 6.6 N.A. N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: 20.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 39.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 40 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 19 0 19 10 0 0 10 10 0 0 0 10 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 0 0 0 0 10 10 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 0 10 0 19 10 0 10 % E
% Phe: 0 0 0 0 0 10 0 10 0 0 0 0 0 10 0 % F
% Gly: 0 55 0 0 10 0 0 10 0 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 37 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 10 10 10 19 0 55 55 0 10 10 0 10 0 55 10 % K
% Leu: 0 0 0 0 0 0 0 0 19 0 0 0 0 19 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 0 0 0 10 0 0 0 0 10 0 0 % N
% Pro: 28 10 10 55 0 0 10 0 0 0 10 0 10 0 0 % P
% Gln: 10 0 55 0 0 0 0 10 10 0 64 0 0 10 0 % Q
% Arg: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 0 % R
% Ser: 0 0 0 0 10 0 0 55 0 46 0 0 0 0 37 % S
% Thr: 10 10 0 0 0 10 10 10 28 10 10 0 55 0 28 % T
% Val: 0 10 10 10 64 10 10 0 37 10 0 64 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _